Multicomponent reactions (MCRs), surmised as versatile and assorted approaches, have been deployed for the modification of cellulose. The functionalized celluloses enjoy various unique phenomena and properties which render them promising biomaterials for various applications ranging from biomedicine to catalysis. References: https://doi.org/10.1021/acssuschemeng.2c00110 https://doi.org/10.1002/ejoc.202200569